The prehistoric history of Florida, and Ozona in particular, is difficult to prove with any amount of certainty.  This is due of two major factors existing in Florida 12-14,000 years ago.  First, Ozona was probably 60 to 100 miles inland from the Gulf of Mexico due to the large amounts of available water that was frozen on the polar icecaps.  Second, any evidence of coastal peoples at that time are now 400' below the surface in the Gulf, far too deep for archaeological exploration.

It is fairly certain that the first humans to reach Florida were the Paleo Indians.  These small bands of nomadic people first populated North America after crossing the land bridge that appeared between Alaska and Siberia during the last glacial period.  Their travels over the next centuries took them as far east as Virginia and as far south as the southern tip of South America.  No one knows why these people journeyed from one continent to the other, but archaeologists have reasoned for some time that they may have been following herds of horses, caribou or mammoth. In addition, as they traveled further and further south they would have found friendlier environments with increasing amounts of editable plant life and more abundant wildlife. 

Many Paleo Indian sites have been found on the outskirts of what used to be large bodies of water such as old glacial lakes, rivers and limestone catchment basins. They probably camped at the water's edge hoping to ambush the animals that came to drink. In northeastern Pennsylvania, archaeologists have found the remains of blackberry and ground-cherry plants on Paleo Indian sites, suggesting that these foods were an important part of their diet. Other artifacts found at Paleo Indian sites include a variety of stone tools that were used to efficiently kill and process meat. The tools may also have been used to work on animal hides, bone and wood, but because these items decay with time, they are typically not found on sites this old.

Artifacts from established communities have been dated as long ago as 13,000 years.  Common sense would suggest that those peoples existed prior to that time and had been moving away from the coast as the ice caps melted and the water rose.

Of the many indigenous peoples, the largest known were the Ais, the Apalachee, the Calusa, the Timucua and the Tocobago tribes.